The TLR-M-CSF axis is implicated in increased bone turnover and curve progression in adolescent idiopathic scoliosis
Authors' conclusion
Together, our findings suggest that the TLR-M-CSF axis is implicated in osteoclastogenesis, resulting in increased bone turnover and may contribute to curve progression in AIS patients.
Study context
- Population
- Age-matched adolescent idiopathic scoliosis (AIS) patients and non-scoliotic individuals; facet joint cartilage
- Comparison
- Facet joint chondrocytes of AIS patients vs non-scoliotic individuals
- Outcome
- Molecular mechanisms of cartilage-bone crosstalk in AIS facet joints
Methodological detailsunbiased deep RNA sequencing, age-matched, in vitro osteoclastogenesis model
- Unbiased deep RNA sequencing
- Age-matched
- In vitro osteoclastogenesis model
Main finding
As reported in the abstract
- Upregulated genes detected in AIS chondrocytes
- 1426
Original publication
The TLR-M-CSF axis is implicated in increased bone turnover and curve progression in adolescent idiopathic scoliosis. Arthritis Res Ther. Published 31 March 2025. doi:10.
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