The Relationship between the complement system and subclinical carotid atherosclerosis in patients with rheumatoid arthritis
Authors' conclusion
The complement system and subclinical carotid atherosclerosis are linked in patients with RA.
Study context
- Population
- Patients with rheumatoid arthritis (RA)
- Participants
- 430 patients
- Outcome
- Association between complement system (functional assays of three pathways and serum levels of individual components) and carotid intima media thickness and carotid plaque (ultrasonography)
Methodological detailsmultivariable linear regression analysis
- Multivariable linear regression analysis
Main finding
As reported in the abstract
- After multivariable adjustment, C3a and C5a significantly positively correlated with carotid intima media thickness
- Higher C1-inhibitor, properdin, C3, C5 and C5a independently associated with presence of carotid plaque
- Adjusted for traditional cardiovascular (CV) risk factors and disease-related data
Observational data: associations, not effects.
Original publication
The Relationship between the complement system and subclinical carotid atherosclerosis in patients with rheumatoid arthritis. Arthritis Res Ther. Published 8 July 2024. doi:10.
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