The prevalence and independent risk factors of elevated common carotid artery intima-media thickness and carotid plaque in patients with gout
Authors' conclusion
Thick CCAIMT and carotid plaque are prevalent in gout patients, whose occurrence relates to age, disease duration, ALP, LDLC, SUA, TG, and tophus.
Study context
- Population
- Gout patients evaluated by bilateral carotid artery US
- Participants
- 237 vs 80
- Exposure
- Gout patients vs healthy controls
- Goutn = 237
- Healthy controlsn = 80reference
- Outcome
- Prevalence and risk factors of thick CCAIMT (>0.9 mm) and carotid plaque
Methodological detailsforward-stepwise multivariate logistic regression, ROC curve analysis
- Forward-stepwise multivariate logistic regression
- ROC curve analysis
Main finding
As reported in the abstract
Prevalence of thick CCAIMT (>0.9 mm) and carotid plaque in gout patients
| Group | Value | Thick common carotid artery intima-media thickness (CCAIMT) prevalence | Carotid plaque prevalence |
|---|---|---|---|
| Gout | 22.4% | 22.4% | 34.6% |
Gout
Value22.4%
Thick common carotid artery intima-media thickness (CCAIMT) prevalence22.4%
Carotid plaque prevalence34.6%
- Gout vs Healthy controls: both p<0.001 — both increased in gout patients
Observational data: associations, not effects.
Further findings
Independent risk factors of thick CCAIMT (multivariate logistic regression), gout patients
- Age, OR (p<0.001)
- 1.143
- Disease duration, OR (p=0.001)
- 1.176
- Alkaline phosphatase (ALP), OR (p=0.002)
- 1.037
- Low-density lipoprotein cholesterol (LDLC), OR (p=0.039)
- 2.144
- sUA, OR (p=0.002), opposite trend
- 0.992
- Combination, AUC
- 0.910
Independent risk factors of carotid plaque (multivariate logistic regression), gout patients
- Age, OR (p<0001)
- 1.116
- Tophus, OR (p=0.009)
- 3.523
- Triglycerides (TG), OR (p=0.014)
- 1.323
- sUA, OR (p=0.008), opposite trend
- 0.995
- Combination, AUC
- 0.886
Original publication
The prevalence and independent risk factors of elevated common carotid artery intima-media thickness and carotid plaque in patients with gout. Clin Exp Rheumatol. Published 12 May 2023. doi:10.
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