The osteoarticular features of Gitelman Syndrome: Chondrocalcinosis and more
Authors' conclusion
CPPD presents in 41.82% of patients with GS. Low serum magnesium and decreased eGFR are risk factors for CPPD. In addition to chondrocalcinosis, GS may be associated with other osteoarticular manifestations, including dense bone islands and condensing osteitis.
Study context
- Population
- Patients with clinically and genetically diagnosed Gitelman Syndrome (GS), Chinese cohort (mean age 39.90±13.70 years, 52.73% females)
- Participants
- 110 patients
- Exposure
- CPPD vs non-chondrocalcinosis osteoarticular abnormalities vs non-radiographic GS
- CPPDn = 46
- Non-chondrocalcinosis abnormalitiesn = 15
- Non-radiographic GSn = 49reference
- Outcome
- Clinical and radiographic osteoarticular features
Methodological detailssystematic screening
- Systematic screening
Main finding
As reported in the abstract
Radiographic classification
Observational data: associations, not effects.
Further findings
- Arthralgia in CPPD
- 78.26%
Arthralgia (all patients)
- Reported arthralgia
- 46 (41.82%)
Age, serum magnesium and estimated glomerular filtration rate (eGFR), CPPD vs non-radiographic
- CPPD patients significantly older and had lower serum magnesium and eGFR vs non-radiographic patients
Joint involvement in CPPD
- Knees most frequently involved, followed by cervical spine, Achilles tendon, hips, hands, shoulders, and wrists
Non-chondrocalcinosis findings
- Included dense bone islands and condensing osteitis of the sacroiliac joint
Original publication
The osteoarticular features of Gitelman Syndrome: Chondrocalcinosis and more. Semin Arthritis Rheum. Published 16 November 2025. doi:10.
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