Spondyloarthritis & psoriatic arthritis
The microbiota in axial spondyloarthritis: what have we learned from Mendelian randomisation studies?
Authors' conclusion
These results underscore the interplay of genetics, microbiota, and disease.
Study context
- Population
- Mendelian randomisation (MR) studies evaluating the relationship between the microbiota and axial spondyloarthritis (SpA)8 MR studies
- Outcome
- Predicted microbiota abundances associated with axial SpA (MR)
Methodological detailsAll studies used the MiBioGen microbiota genome-wide association study (GWAS) (one also the Dutch Microbiome Project); disease associations from ankylosing spondylitis (AS) GWAS, FinnGen, UK Biobank and Integrative Epidemiology Unit (IEU) Open GWAS
- All studies used the MiBioGen microbiota GWAS (one also the Dutch Microbiome Project); disease associations from AS GWAS, FinnGen, UK Biobank and IEU Open GWAS
Pooled result
As reported in the abstract
- Predicted increased abundances of Ruminococcaceae NK4A214 and Verrucomicrobia, among others
- Predicted decreased abundances of Lactobacillaceae and Rikenellaceae families and the Bacteroides genus
- Findings largely support cross-sectional microbiota studies in SpA
Original publication
The microbiota in axial spondyloarthritis: what have we learned from Mendelian randomisation studies? Clin Exp Rheumatol. Published 7 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →