Spondyloarthritis & psoriatic arthritis
The impact of diet on disease activity in spondyloarthritis: A systematic literature review
Authors' conclusion
weight loss seem to be able to impact disease activity in PsA, while probiotics do not seem useful in SpA; evidence for dietary behaviors is scarce and heterogeneous.
Study context
- Population
- Adult patients with spondyloarthritis (SpA) (axSpA/pSpA, including PsA)15 studies
- Exposure
- Any diet or dietary supplement in SpA, pre- vs post-intervention
- Outcome
- Disease activity
Methodological detailsMEDLINE, EMBASE, Cochrane and SCOPUS, PEO format, Randomized Controlled Trials (RCTs) and longitudinal studies, risk of bias (RoB) assessed with design-specific tools, 1390 publications screened; 15 included
- MEDLINE, EMBASE, Cochrane and SCOPUS
- PEO format
- RCTs and longitudinal studies
- RoB assessed with design-specific tools
- 1390 publications screened; 15 included
Main finding
As reported in the abstract
Effect of diet/dietary supplements on SpA disease activity
- Probiotics in SpA: 2 RCTs (one unclear, one low RoB) failed to show benefit
- PsA: 2 RCTs at unclear RoB — weight loss, but not hypocaloric diet, associated with MDA achievement
- Remaining interventional studies at high RoB
- axSpA: one observational study — Mediterranean diet adherence associated with ≥ 20% decrease of ASDAS
- Other two observational studies of poor quality
- 12 interventional and 3 observational studies
Observational data: associations, not effects.
Original publication
The impact of diet on disease activity in spondyloarthritis: A systematic literature review. Joint Bone Spine. Published 28 October 2022. doi:10.
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