The impact of concomitant Sjögren's disease on rheumatoid arthritis disease activity: a systematic review and meta-analysis
Authors' conclusion
RA/SS patients appear to have higher disease activity and more functional disability than patients with RA alone.
Study context
- Population
- Individuals with rheumatoid arthritis (RA), with or without concomitant Sjögren's syndrome (SS), in studies reporting RA disease activity scores, joint counts, visual analogue scales (VAS), disability and joint damage
- Participants
- 29,722 individuals16 studies
- Comparison
- RA with concomitant SS vs RA alone
- RA/SSn = 8,614
- RAn = 21,108reference
- Outcome
- RA disease activity and function (meta-analysis: 744 RA/SS, 4450 RA)
Methodological detailsrandom effects model where heterogeneity was detected, no language restriction
- Random effects model where heterogeneity was detected
- No language restriction
Pooled result
As reported in the abstract
RA/SS vs RAMean difference (95% CI)P value
DAS-28 ESR
0.50(−0.008-1.006)
P = 0.05Swollen joint count
1.05(0.42–1.67)
P = 0.001HAQ functional disability
0.19(0.05–0.34)
P = 0.009Original publication
The impact of concomitant Sjögren's disease on rheumatoid arthritis disease activity: a systematic review and meta-analysis. Clin Exp Rheumatol. Published 23 December 2023. doi:10.
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