Predictors for severe persisting pain in rheumatoid arthritis are associated with pain origin and appraisal of pain
Authors' conclusion
Persisting and non-nociceptive pain occur frequently in RA. Besides the potential involvement of NeP, pain catastrophising and a higher number of tender joints coincide with persisting pain.
Study context
- Population
- Outpatients with rheumatoid arthritis (RA) scheduled for escalation of anti-inflammatory treatment due to active disease and severe pain (DAS28>3.2 and Visual Analogue Scale (VAS)>50)
- Participants
- 567 outpatients
- Exposure
- Persisting pain vs reference group vs non-responders at week 24
- Referencen = 337reference
- Non-respondersn = 102
- Persisting painn = 128
- Outcome
- Proportion of patients with RA with severe persisting pain despite treatment-controlled disease activity, and its predictive factors
- Follow-up
- Week 24
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Classification at week 24
- Pain catastrophising positively associated with persisting pain at week 24
- P = 0.002
- Number of tender joints positively associated with persisting pain at week 24
- P = 0.004
Observational data: associations, not effects.
Further findings
Positive for neuropathic pain (PD-Q) · week 24 · reference group reported as "responders"
Original publication
Predictors for severe persisting pain in rheumatoid arthritis are associated with pain origin and appraisal of pain. Ann Rheum Dis. Published 30 September 2024. doi:10.
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