The immune pathology of bursitis in rheumatic inflammatory diseases, degenerative conditions and mechanical stress: A systematic review
Authors' conclusion
Substantial overlap of enhanced expression of IL-6, IL-1β, TNF-α and infiltrating macrophages were found in bursitis irrespective of the underlying cause.
Study context
- Population
- Patients with bursitis caused by inflammatory rheumatic diseases, degenerative conditions or mechanical stress (e.g., impingement syndrome); PubMed/MEDLINE from inception to February 13, 202332 articles
- Outcome
- Immunological changes occurring in the bursa
Pooled result
As reported in the abstract
Immune pathology of bursal tissue inflammation
- Alterations of tissue morphology, infiltration of macrophages and some T cells, and enhanced expression of proinflammatory cytokines (IL-6, IL-1β, TNF-α)
- These changes described for all three underlying causes; studies on bursitis associated with rheumatic inflammatory diseases were rare
- Fibrosis only reported in subacromial bursitis caused by mechanical stress
Original publication
The immune pathology of bursitis in rheumatic inflammatory diseases, degenerative conditions and mechanical stress: A systematic review. Semin Arthritis Rheum. Published 3 August 2024. doi:10.
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