Systemic sclerosis & Raynaud's
The differential crosstalk of the skin–gut microbiome axis as a new emerging actor in systemic sclerosis
Authors' conclusion
Different microbiota signatures and FFA profiles were found for the two groups of patients. Despite being in different body districts, the cutaneous Sphingobacteria and faecal Lentisphaerae appear interdependent.
Study context
- Population
- SSc patients with ACA or anti-Scl70 autoantibodies
- Participants
- 25 patients
- Exposure
- ACA+ vs anti-Scl70+ SSc patients
- Outcome
- Skin, oral and gut microbiota and serum and faecal FFA profiles
Methodological detailsnext-generation sequencing, GC-MS
- Next-generation sequencing
- GC-MS
Main finding
As reported in the abstract
- Correlation of cutaneous Sphingobacteria and faecal Lentisphaerae
- rho = 0.42; P = 0.03
- Faecal medium-chain free fatty acid (FFAs) significantly higher in ACA+ vs anti-Scl70+
- P < 0.05
- Faecal hexanoic acids significantly higher in ACA+ vs anti-Scl70+
- P < 0.001
Observational data: associations, not effects.
Original publication
The differential crosstalk of the skin–gut microbiome axis as a new emerging actor in systemic sclerosis. Rheumatology (Oxford). Published 8 May 2023. doi:10.
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