Test–Retest Reliability and Sensitivity to Change of Ultrasound‐Based Methods of Measuring Synovial Inflammation in Knee Osteoarthritis
Authors' conclusion
In a clinical setting, US measures of inflammatory features of knee OA have substantial reliability and low-to-moderate sensitivity to change, whereas measures of structural OA features are less reliable.
Study context
- Population
- Patients with symptomatic knee osteoarthritis (OA) in stable condition; knee OA patients receiving intraarticular GC injectionreliability 36 patients (70 knees)
- Outcome
- Test-retest reliability of US measures of inflammation
- Follow-up
- 2 assessments within 14 days
Methodological detailstest–retest reliability and sensitivity to change, test–retest within 14 days, different operators and different ultrasound (US) machines, single rater, longitudinal before and 21-28 days after intraarticular GC injection
- Test–retest reliability and sensitivity to change
- Test–retest within 14 days
- Different operators and different US machines
- Single rater
- Longitudinal before and 21-28 days after intraarticular GC injection
Main finding
As reported in the abstract
US measures of inflammation: moderate agreement (Cohen's κ)
κ = 0.41, 0.60
US measures of inflammation: substantial agreement (Cohen's κ)
κ = 0.61, 0.80
Observational data: associations, not effects.
Further findings
Longitudinal construct validity: changes in US measures vs KOOS pain · 21-28 days after injection
- Associations low; 95% CIs included zero
- Multivariate linear regression adjusted for covariates
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Test–Retest Reliability and Sensitivity to Change of Ultrasound‐Based Methods of Measuring Synovial Inflammation in Knee Osteoarthritis. Arthritis Care Res (Hoboken). Published 12 December 2022. doi:10.
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