Lupus & antiphospholipid syndrome
Systemic Lupus Erythematosus and Mortality in Elderly Patients With Early Breast Cancer
Main finding · Death (Cox multivariable model)Result — go to the resultHazard ratio 1.65 95% CI 1.38–1.98Authors' conclusion
Systemic lupus is a risk factor for increased mortality in women with early BC.
Study context
- Population
- Elderly women with breast cancer in the Texas Cancer Registry and Surveillance, Epidemiology, and End Results, linked to Medicare claims9,708 non-SLE matched
- Exposure
- Breast cancer with systemic lupus erythematosus (SLE) vs breast cancer without SLE
- Breast cancer (BC) SLEn = 494
- BC non-SLEn = 145,517reference
- Outcome
- Overall survival
Methodological detailsmatched (age and cancer stage), multivariable Cox proportional hazards models, Texas Cancer Registry and SEER linked to Medicare claims
- Matched (age and cancer stage)
- Multivariable Cox proportional hazards models
- Texas Cancer Registry and SEER linked to Medicare claims
Main finding
Death (Cox multivariable model)
Hazard ratio
1.65
95% CI 1.38–1.98
BC SLEvs BC non-SLE
HR 1.65 (95% CI 1.38–1.98)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Death, BC with SLEvs SLE without cancerAfter adjusting for SLE severity | 1.42 (1.05–1.92) | |
| 0.512Hazard ratio (log scale) |
| Outcome | BC SLE | BC non-SLE |
|---|---|---|
| 8-year OS, early BC (stages 0-II) | 52% (95% CI 45%–59%) | 74% (95% CI 73%–75%) |
Cancer treatment
- Women with SLE less likely to receive radiation, breast conserving surgery, or endocrine therapy
SLE medications after cancer diagnosis
- Women with SLE and BC received less GC, antimalarials, and immunosuppressants than those without cancer
Original publication
Systemic Lupus Erythematosus and Mortality in Elderly Patients With Early Breast Cancer. Arthritis Care Res (Hoboken). Published 26 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →