Standardized nailfold capillaroscopy in children with rheumatic diseases: a worldwide study
An erratum to this article was published (Rheumatology (Oxford), 5 Jul 2023 ↗)
Authors' conclusion
The NVC assessment in jRMD differed significantly from HCs.
Study context
- Population
- Consecutive children and adolescents with juvenile rheumatic and musculoskeletal diseases (jRMD) and matched healthy controls (HCs), 13 centres worldwide (mean age 12.1 years, 70.9% female)6,474 images assessed
- Participants
- 413 children
- Exposure
- Children with jRMD vs matched HCs
- JIAn = 95
- JDMn = 22
- cSLEn = 20
- jSScn = 13
- Localized scleroderma (lSc)n = 21
- MCTDn = 18
- Primary RP (PRP)n = 20
- Outcome
- NVC characteristics (density, dilations, abnormal shapes, haemorrhages; qualitative patterns) vs HCs
Methodological detailsmulticentre (13 centres worldwide), matched healthy controls, central reading per EULAR consensus standard evaluation, multivariable regression analysis
- Multicentre (13 centres worldwide)
- Matched healthy controls
- Central reading per EULAR consensus standard evaluation
- Multivariable regression analysis
Main finding
As reported in the abstract
- Density: significantly lower in jSSc, JDM, MCTD, cSLE and lSc vs HCs
- Dilations: significantly higher in jSSc, MCTD and JDM vs HCs
- Abnormal shapes: significantly higher in JDM and MCTD vs HCs
- Haemorrhages: significantly higher in jSSc, MCTD, JDM and cSLE vs HCs
- Qualitative nailfold videocapillaroscopy (NVC) assessment of JIA, lSc and PRP did not differ from HCs
- cSLE showed more non-specific patterns; jSSc, MCTD, JDM and cSLE showed more scleroderma patterns
Observational data: associations, not effects.
Original publication
Standardized nailfold capillaroscopy in children with rheumatic diseases: a worldwide study. Rheumatology (Oxford). Published 25 August 2022. doi:10.
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