Standardized 3D-CT lung volumes for patients with acute exacerbation of rheumatoid arthritis-associated interstitial lung disease
Authors' conclusion
Volume loss at AE in patients with RA-ILD was associated with increased mortality.
Study context
- Population
- Patients with RA-ILD at diagnosis and at acute exacerbation (AE), and controls
- Participants
- 54 / 20 / 33 / 35
- Exposure
- RA-ILD at AE vs RA-ILD at diagnosis vs controls
- RA-ILD at diagnosisn = 54
- AE discoveryn = 20
- AE validationn = 33
- Controlsn = 35reference
- Outcome
- LV measured by 3D-CT and standardized by predicted FVC; association with disease severity and mortality risk in AE-RA-ILD
Methodological detailsdiscovery and validation cohorts, quantitative 3D-CT, multivariate analyses
- Discovery and validation cohorts
- Quantitative 3D-CT
- Multivariate analyses
Main finding
As reported in the abstract
- RA-ILD at diagnosis: decreased lung volume (LV), predominantly in lower lobes, vs controls
- Further substantial volume loss in upper and lower lobes at AE vs at diagnosis
- During AE, decreased standardized 3D-CT LV associated with worse prognosis in both cohorts
- Standardized 3D-CT LV a significant prognostic factor independent of age, sex and UIP pattern on CT (multivariate analyses)
- Composite model of age and standardized 3D-CT LV classified mortality risk in AE-RA-ILD
Observational data: associations, not effects.
Original publication
Standardized 3D-CT lung volumes for patients with acute exacerbation of rheumatoid arthritis-associated interstitial lung disease. Rheumatology (Oxford). Published 17 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →