Sputum lautropia is decreased in rheumatoid arthritis-associated pulmonary fibrosis
Main finding · Undetectable Lautropia (multivariable, adjusted for age, sex, smoking)Result — go to the resultOdds ratio 0.14Authors' conclusion
Sputum Lautropia is significantly reduced in RA-PF, and its absence may correlate with more severe fibrosis.
Study context
- Population
- RA patients from rheumatology and pulmonary clinics
- Participants
- 54 patients
- Exposure
- RA with pulmonary fibrosis vs RA without fibrosis
- Rheumatoid arthritis and pulmonary fibrosis (RA-PF)n = 22
- RA-no-PFn = 32reference
- Outcome
- Lung (sputum) microbial composition: relative abundance of sputum bacteria
Methodological details16S rRNA sequencing of induced sputum, three independent analytic approaches (Mann-Whitney U, DESeq2, EdgeR) with false discovery rate correction, multivariable logistic regression
- 16S rRNA sequencing of induced sputum
- Three independent analytic approaches (Mann-Whitney U, DESeq2, EdgeR) with false discovery rate correction
- Multivariable logistic regression
Main finding
As reported in the abstract
Undetectable Lautropia (multivariable, adjusted for age, sex, smoking)
Odds ratio
0.14
P = 0.023
Observational data: associations, not effects.
Further findings
Within RA-PF, undetectable Lautropia
- No difference in pulmonary physiology but a trend towards more lung fibrosis
Original publication
Sputum lautropia is decreased in rheumatoid arthritis-associated pulmonary fibrosis. Arthritis Res Ther. Published 17 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →