Spondyloarthritis & psoriatic arthritis
Short‐Term Response to Biologic Therapy in Psoriatic Arthritis Is Not Influenced by Disease Duration at Initiation of Therapy
Authors' conclusion
Short-term response to biologic therapy in patients with PsA does not appear to differ between those treated early or later in the disease course.
Study context
- Population
- Biologic-naive patients with psoriatic arthritis (PsA) who started biologic therapy from 2000 to 2025
- Participants
- 228 patients
- Exposure
- Biologic started within 2 years of PsA diagnosis vs later
- Early treatmentn = 71
- Delayed treatmentn = 157reference
- Outcome
- ≥50% reduction in DAPSA score
- Follow-up
- Six months
Methodological detailspropensity score regression adjusted, logistic regression
- Propensity score regression adjusted
- Logistic regression
Main finding
As reported in the abstract
≥50% reduction in DAPSA
- Propensity score regression adjusted analysis did not suggest a difference in response at six months between early and delayed treatment
Observational data: associations, not effects.
Original publication
Short‐Term Response to Biologic Therapy in Psoriatic Arthritis Is Not Influenced by Disease Duration at Initiation of Therapy. Arthritis Care Res (Hoboken). Published 21 July 2026. doi:10.
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