Spondyloarthritis & psoriatic arthritis
Sex-specific disparities in disease activity scores among patients with axial spondyloarthritis and their implications for evaluating the response to tumor necrosis factor alpha inhibitor therapy
Authors' conclusion
The changes in disease activity before and after TNFi use were significantly different between sexes when measured by BASDAI, but not ASDAS.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) who started or changed TNFi, KOBIO registry, Korea1,343 (76.6%) male
- Participants
- 1,753 patients
- Exposure
- Male vs female patients with axSpA starting TNFi
- Malen = 1,343
- Outcome
- Sex differences in change in BASDAI and ASDAS from baseline to 1 year after TNFi initiation
- Follow-up
- One year
Methodological detailsregistry-based (KOBIO), adjusted for baseline characteristics
- Registry-based (KOBIO)
- Adjusted for baseline characteristics
Main finding
As reported in the abstract
BASDAI change independently associated with sex (β)
0.343
p = 0.011
Ankylosing Spondylitis Disease Activity Score (ASDAS) change not associated with sex (β)
0.079
p = 0.235
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| TNFi assessed as effective by BASDAI criterion (ΔBASDAI ≥ 50% or ≥ 2) · one yearMalevs FemaleAdjusted for other baseline characteristics | 1.700 (1.200–2.406) | |
| TNFi assessed as effective by ASDAS criterion (ΔASDAS ≥ 1.1) · one yearMalevs FemaleAdjusted for other baseline characteristics | 0.993 (0.678–1.455) | |
| 0.512Odds ratio (log scale) |
Baseline disease activity, all patients
- Mean BASDAI
- 5.98
- Mean ASDAS
- 3.6
Original publication
Sex-specific disparities in disease activity scores among patients with axial spondyloarthritis and their implications for evaluating the response to tumor necrosis factor alpha inhibitor therapy. Arthritis Res Ther. Published 25 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →