Systemic sclerosis & Raynaud's
Sex influence on outcomes of patients with systemic sclerosis–associated interstitial lung disease: a EUSTAR database analysis
Authors' conclusion
Male SSc-ILD patients have a poorer prognosis and sex-specific predictors exist in SSc-ILD.
Study context
- Population
- EUSTAR systemic sclerosis (SSc) patients with radiologically confirmed interstitial lung disease (ILD) and available %pFVC
- Participants
- 1,136 vs 5,253
- Exposure
- Male vs female SSc-ILD patients
- Malesn = 1,136
- Femalesn = 5,253reference
- Outcome
- Change in %pFVC classified as stable (≤4%), mild (5-9%) and large progression (≥10%)
- Follow-up
- 12 months (s.d. 6)
Methodological detailsEUSTAR database analysis, logistic regression, Cox proportional hazards models adjusted for age and %pFVC
- EUSTAR database analysis
- Logistic regression
- Cox proportional hazards models adjusted for age and %pFVC
Main finding
As reported in the abstract
Stable ILD (cohort 1)
P = 0.056
Observational data: associations, not effects.
Further findings
Predictors of large progression in males (cohort 1, multivariable)
| OR for large progression (95% CI) | ||
|---|---|---|
| Disease duration | 0.99 (0.98–0.99) | |
| %pFVC | 0.97 (0.95–0.99) | |
| 0.512OR for large progression (log scale) |
Predictors of large progression in females (cohort 1, multivariable)
| OR for large progression (95% CI) | ||
|---|---|---|
| Age | 1.02 (1.00–1.04) | |
| %pFVC | 0.97 (0.96–0.98) | |
| Anti-centromere | 0.39 (0.245–0.63) | |
| 0.20.5125OR for large progression (log scale) |
1-year mortality rate (cohort 1)
P = 0.013
Periods of large progression (cohort 2) · 2 years
P = 0.023
Mortality: overall death rate and male sex as predictor (survival analysis, cohort 2) · overall death rate
P < 0.001
| Outcome | OR for mortality (95% CI) |
|---|---|
| Mortality: overall death rate and male sex as predictor (survival analysis, cohort 2)Survival analysis | 1.95 (1.66–2.28) |
- Stable ILD over 12 months (cohort 1)
- P = 0.056
Periods of large progression (cohort 2) · 2 years
- Percentage with none, one or two periods of worsening not different
Original publication
Sex influence on outcomes of patients with systemic sclerosis–associated interstitial lung disease: a EUSTAR database analysis. Rheumatology (Oxford). Published 22 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →