Systemic sclerosis & Raynaud's
Disease specific determinants of cardiopulmonary fitness in systemic sclerosis
Authors' conclusion
SSc is associated with marked functional impairment that is not explained by commonly used parameters of cardiac function such as left ventricular ejection fraction.
Study context
- Population
- Systemic sclerosis (SSc) patients with no history of cardiac disease and no active myositis, undergoing cardiac and skeletal muscle MRI, echocardiography, pulmonary function tests and cardiopulmonary exercise testing (CPET)
- Exposure
- SSc patients vs matched controls with no overt cardiopulmonary disease
- SScn = 33
- Outcome
- Exercise capacity (peak VO2) and its disease-specific determinants
Methodological detailsage-, sex-, and weight-matched controls, linear regression analysis
- Age-, sex-, and weight-matched controls
- Linear regression analysis
Main finding
As reported in the abstract
Percent predicted peak VO2
P < 0.01
- Diffuse myocardial fibroinflammatory disease significantly associated with reduced exercise capacity
- P < 0.01
- Skeletal muscle oedema significantly associated with reduced exercise capacity
- P = 0.01
Observational data: associations, not effects.
Original publication
Disease specific determinants of cardiopulmonary fitness in systemic sclerosis. Semin Arthritis Rheum. Published 17 November 2022. doi:10.
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