Sex differences in preoperative pain intensity among patients undergoing total knee arthroplasty: A propensity score–matched cross-sectional study
Authors' conclusion
Women with advanced knee OA awaiting surgery showed greater pain sensitivity and human-assumed central sensitization than men, independent of structural and inflammatory factors.
Study context
- Population
- Patients with advanced knee osteoarthritis (OA) undergoing total knee arthroplasty (preoperative)matched 1:1
- Participants
- 120 patients
- Exposure
- Women vs men with advanced knee OA
- Womenn = 60
- Menn = 60reference
- Outcome
- Pain intensity at rest and during movement
Methodological detailspropensity score-matched 1:1 on age, BMI, Kellgren-Lawrence grade, CRP, synovitis and bone marrow lesions
- Propensity score-matched 1:1 on age, BMI, Kellgren-Lawrence grade, CRP, synovitis and bone marrow lesions
Secondary outcomes
| Outcome | Women | Men | Mean difference (mm) (95% CI) | |
|---|---|---|---|---|
| Resting pain (primary) | 23.3 ± 22.3 | 11.0 ± 15.2 | 12.3 (5.1–19.5) | |
| Movement pain (primary) | 47.2 ± 25.0 | 45.3 ± 24.6 | 1.9 (−7.4 to 11.2) | |
| −1001020Difference, mm (linear scale) |
CSI-9, pressure pain thresholds (PPTs), physical function, psychosocial measures
- Women: higher CSI-9 scores, lower PPTs at knee and forearm, poorer physical function; no significant differences in psychosocial measures
Original publication
Sex differences in preoperative pain intensity among patients undergoing total knee arthroplasty: A propensity score–matched cross-sectional study. Osteoarthritis Cartilage. Published 19 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →