Serum calprotectin correlates stronger with inflammation and disease activity in ACPA positive than ACPA negative rheumatoid arthritis
Authors' conclusion
The particularly strong association between circulating calprotectin and inflammation in ACPA positive RA is a new argument for a specific role for polymorphonuclear granulocytes/neutrophils in this RA subset. Measurement of calprotectin in SF does not convey any additional benefit compared with measurement in the circulation in RA patients with knee synovitis.
Study context
- Population
- RA patients with ongoing knee synovitis
- Participants
- 76 patients
- Exposure
- Serum vs SF calprotectin as inflammatory biomarker; ACPA positive vs ACPA negative RA
- Outcome
- Performance of serum and SF calprotectin as inflammatory biomarker (correlation with inflammatory markers and disease activity)
Main finding
As reported in the abstract
SF-calprotectin correlation with SF polymorphonuclear cell counts (Spearman's ρ), P < 0.001
0.72
Observational data: associations, not effects.
Original publication
Serum calprotectin correlates stronger with inflammation and disease activity in ACPA positive than ACPA negative rheumatoid arthritis. Rheumatology (Oxford). Published 4 December 2023. doi:10.
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