Serum alarmins and the risk of incident interstitial lung disease in rheumatoid arthritis
Authors' conclusion
In this study, we observed a significant inverse association between serum IL-33 concentration and the risk of developing incident RA-ILD, but no associations with prevalent ILD.
Study context
- Population
- Patients with RA in a multicentre prospective RA cohort; serum collected at enrolment
- Participants
- 2,835 patients
- Exposure
- Serum alarmins concentrations and RA-ILD risk
- Outcome
- Incident RA-ILD developing after enrolment (and prevalent RA-ILD at enrolment)
Methodological detailsmulticentre, logistic regression (prevalent RA-ILD), Cox proportional hazards (incident RA-ILD)
- Multicentre
- Logistic regression (prevalent RA-ILD)
- Cox proportional hazards (incident RA-ILD)
Main finding
As reported in the abstract
Incident RA-ILD per log-fold increase in IL-33
IL-33 (per log-fold increase)Hazard ratio (95% CI)P value
Unadjusted
0.73(0.57–0.95)
P = 0.018Adjusted
0.77(0.59–1.00)
P = 0.047Per log-fold increase, as printed
- Incident ILD developed
- 146 (5.1%)
Observational data: associations, not effects.
Further findings
Prevalent RA-ILD at baseline · enrolment
- Prevalent RA-ILD at baseline
- 115 (4.1%)
- No associations between serum alarmin concentrations and prevalent ILD in unadjusted or adjusted models
Original publication
Serum alarmins and the risk of incident interstitial lung disease in rheumatoid arthritis. Rheumatology (Oxford). Published 9 October 2023. doi:10.
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