Scleritis and Development of Immune-Mediated Disease: A Retrospective Chart Review
Authors' conclusion
At our ophthalmology center, 43% of patients with scleritis had an associated IMD, and most patients with an IMD were symptomatic from this disease prior to scleritis presentation. RA was the most commonly associated condition and typically predated the scleritis, whereas vasculitis was more likely diagnosed during or after the scleritis episode. Scleritis among patients with IMD is more likely to recur compared to scleritis that is idiopathic.
Study context
- Population
- Patients with scleritis seen at a tertiary care center, January 1, 2005 to December 31, 2020
- Participants
- 341 patients
- Exposure
- Immune-mediated disease (IMD)-associated scleritis vs idiopathic scleritis
- IMDn = 145
- Outcome
- Proportion of patients with scleritis with an associated IMD
Methodological detailsretrospective chart review, single tertiary care centre
- Retrospective chart review
- Single tertiary care centre
Main finding
As reported in the abstract
Associated IMD among patients with scleritis
IMD
43%
145
- Most common IMDs: Rheumatoid arthritis (RA)
- 39%
- Most common IMDs: vasculitis
- 21%
- Most common IMDs: inflammatory bowel disease
- 14%
- IMD diagnosis predated scleritis presentation
- 63%
Observational data: associations, not effects.
Further findings
Recurrence of scleritis
P = 0.02
Demographics and treatment failures
- No significant differences between scleritis with and without associated IMDs
Original publication
Scleritis and Development of Immune-Mediated Disease: A Retrospective Chart Review. J Rheumatol. Published 1 February 2024. doi:10.
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