Lupus & antiphospholipid syndrome
Risk of human papillomavirus (HPV)-associated precancer and cancer in women with systemic lupus erythematosus
Authors' conclusion
Women in this nationwide SLE cohort had twice the risk of cervical precancer (vs the general population) and up to 5-fold increased risk of the individual noncervical anogenital precancers. Rates of oropharyngeal cancer and the anogenital cancers were not statistically significantly increased; however, estimates were based on few cases.
Study context
- Population
- All women in Denmark with a first diagnosis of systemic lupus erythematosus (SLE) recorded in the nationwide Patient Registry during 1996–2021, followed up until 2022
- Participants
- 5,092 women
- Exposure
- Women with SLE vs general female population rates
- SLEn = 5,092
- Outcome
- HPV-associated precancer and cancer
Methodological detailsregistry-based, standardised incidence ratios vs general female population rates
- Registry-based
- Standardised incidence ratios vs general female population rates
Main finding
As reported in the abstract
HPV-associated precancers
SLE vs General populationStandardized incidence ratio (95% CI)
Cervical precancer
2.3(2.0–2.7)
Vaginal precancer
4.3(1.1–9.5)
Vulvar precancer
3.7(2.3–5.5)
Anal precancer
4.3(1.7–8.1)
Observational data: associations, not effects.
Further findings
Cervical and anal cancer
- Increased cancer rates observed for cervix and anus, not statistically significant
- Estimates based on few cases
Precancers and cancers by follow-up time and age at SLE diagnosis
- Increased standardised incidence ratios (SIRs) sustained throughout follow-up
- SIRs higher in women diagnosed with SLE at age <50 years vs ≥50 years, but CIs overlapping
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Risk of HPV-associated precancer and cancer in women with systemic lupus erythematosus. Ann Rheum Dis. Published 31 January 2025. doi:10.
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