Risk of Heart Failure in Patients With Immune-Mediated Inflammatory Diseases: A Population-Based Study
Authors' conclusion
The risk of HF hospitalization is increased in patients with IMID compared to the general population.
Study context
- Population
- Patients with rheumatoid arthritis (RA), radiographic axial spondyloarthritis (r-axSpA), PsA and psoriasis (PsO) in Ontario, 2011–2019, vs general population with and without diabetes mellitus (DM)
- Participants
- 243,061 / 748,517 / 8,278,934
- Exposure
- IMID vs non-IMID, non-DM controls; DM as comparison
- IMIDn = 243,061
- DMn = 748,517
- Non-IMID, non-DM controlsn = 8,278,934reference
- Outcome
- First hospitalization for HF
Methodological detailsCox proportional hazard models
- Cox proportional hazard models
Main finding
As reported in the abstract
HF hospitalization
IMID
2.70
crude incidence rate · per 1000 person-years
Each group vs Non-IMID, non-DM controlsHazard ratio (95% CI)
IMID
1.34(1.30–1.38)
DM
2.19(2.16–2.21)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| HF hospitalization by IMID: RA (highest risk)RAvs Non-IMID, non-DM controls | 1.61 (1.54–1.68) | |
| HF hospitalization by IMID: PsO (lowest risk)PsOvs Non-IMID, non-DM controls | 1.09 (1.03–1.15) | |
| 0.512Hazard ratio (log scale) |
Heart failure (HF) etiology (antecedent comorbidity)
- Most common antecedent comorbidity in all IMID: ischemic heart disease
- In IMID without DM, AF had a similar effect as ischemic heart disease
- Descriptive classification
Original publication
Risk of Heart Failure in Patients With Immune-Mediated Inflammatory Diseases: A Population-Based Study. J Rheumatol. Published 1 March 2025. doi:10.
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