Risk of fracture in neuromyelitis optica spectrum disorder and multiple sclerosis: a nationwide cohort study in South Korea
Study context
- Population
- Patients with multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD) in the Korean National Health Insurance Service (NHIS) database, January 2010 to December 2017matched cohort
- Exposure
- MS and NMOSD vs matched controls
- MSn = 1,217
- NMOSDn = 1,329
- Outcome
- Risk of fracture (any)
Methodological detailsnationwide, matched controls (age, sex, hypertension, diabetes mellitus, dyslipidemia), Mean follow-up 4.73/4.28 years for matched controls of MS/NMOSD
- Nationwide
- Matched controls (age, sex, hypertension, diabetes mellitus, dyslipidemia)
- Mean follow-up 4.73/4.28 years for matched controls of MS/NMOSD
Main finding
As reported in the abstract
Any fracture · mean follow-up 4.40/4.08 years (MS/NMOSD)
Each group vs controlsAdjusted hazard ratio (95% CI)
MS
1.81(1.43–2.28)
NMOSD
1.85(1.47–2.34)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Hip fractureMSvs Controls | 3.36 (1.81–6.24) | |
| Hip fractureNMOSDvs Controls | 3.82 (2.05–7.11) | |
| Vertebral fractureMSvs Controls | 2.01 (1.42–2.99) | |
| Vertebral fractureNMOSDvs Controls | 2.84 (1.92–4.21) | |
| 0.10.31310Adjusted hazard ratio (log scale) |
Fracture incidence, MS vs NMOSD
- No significant differences in fracture incidence between MS and NMOSD
Original publication
Risk of fracture in neuromyelitis optica spectrum disorder and multiple sclerosis: a nationwide cohort study in South Korea. Osteoporos Int. Published 28 February 2023. doi:10.
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