Ethnic disparities in fracture risk assessment using polygenic scores
Authors' conclusion
These results showed that PGSs based on common BMD-related genetic variants discovered in the European ancestry cohort are predictive of fracture risk in people of Asian but not African ancestry.
Study context
- Population
- UK Biobank participants aged 40–69 years with genotypic and phenotypic dataUK Biobank
- Participants
- 502,617 participants
- Exposure
- Ancestry groups: association of bone mineral density (BMD)-related PGSs with fracture
- Outcome
- Association between each PGS (from genome-wide association studies (GWAS) of femoral neck and total body BMD) and prevalent/incident fractures within each ethnic group
Methodological detailspopulation-based, multivariate logistic regression, Cox proportional hazard models, adjusted for age, sex and first four principal components
- Population-based
- Multivariate logistic regression
- Cox proportional hazard models
- Adjusted for age, sex and first four principal components
Main finding
As reported in the abstract
Fracture per SD decrease in best-performing PGS
| Group | HR |
|---|---|
| European | 1.24 (1.22-1.27) |
| African | 1.28 (0.83-1.99) |
| Asian | 1.34 (1.10-1.64) |
HR
European1.24 (1.22-1.27)
African1.28 (0.83-1.99)
Asian1.34 (1.10-1.64)
Observational data: associations, not effects.
Further findings
Fracture risk with low BMD-related PGS
- Up to fold increased fracture risk, European
- 2.35
- Up to fold increased fracture risk, Asian
- 4.31
Original publication
Ethnic disparities in fracture risk assessment using polygenic scores. Osteoporos Int. Published 25 February 2023. doi:10.
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