Risk of COVID‐19 Among Unvaccinated and Vaccinated Patients With Rheumatoid Arthritis: A General Population Study
Authors' conclusion
Patients with RA are still at higher risks of SARS-CoV-2 infection and COVID-19 hospitalization than the general population after receiving COVID-19 vaccines.
Study context
- Population
- Unvaccinated and vaccinated patients with rheumatoid arthritis (RA) and the general population, UK primary care database
- Exposure
- RA vs general population, unvaccinated and vaccinated
- Outcome
- SARS-CoV-2 infection, hospitalization and death from COVID-19
Methodological details2 cohort studies by COVID-19 vaccination status, exposure score overlap weighting, UK primary care database
- 2 cohort studies by COVID-19 vaccination status
- Exposure score overlap weighting
- UK primary care database
Main finding
As reported in the abstract
Unvaccinated: weighted incidence rates and adjusted hazard ratios (HRs) · 3 months of follow-up
RA vs General populationEstimate (95% CI)
Rates 9.21vs 8.16 of 1,000 person-months
adjusted HR, SARS-CoV-2 infection 1.10(1.00–1.24)
Rates 3.46vs 2.14 of 1,000 person-months
adjusted HR, hospitalization 1.62(1.34–1.96)
Rates 1.19vs 0.62 of 1,000 person-months
adjusted HR, death 1.88(1.37–2.60)
Observational data: associations, not effects.
Further findings
| Outcome | RA | General population | HR (95% CI) | |
|---|---|---|---|---|
| Vaccinated: breakthrough infection · 9 months of follow-up | weighted rate 4.17 of 1,000 person-months | weighted rate 3.96 of 1,000 person-months | 1.10 (1.00–1.20) | |
| Vaccinated: hospitalization · 9 months of follow-up | weighted rate 0.42 of 1,000 person-months | weighted rate 0.32 of 1,000 person-months | 1.29 (0.96–1.75) | |
| 0.512Hazard ratio (log scale) |
Vaccinated: infection and hospitalization at 3 and 6 months · 3 and 6 months of follow-up
- No apparent difference in the risk of these outcomes was observed over 3 and 6 months of follow-up between 2 comparison cohorts
Original publication
Risk of COVID‐19 Among Unvaccinated and Vaccinated Patients With Rheumatoid Arthritis: A General Population Study. Arthritis Care Res (Hoboken). Published 17 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →