Rheumatoid interstitial lung disease in Canterbury, Aotearoa New Zealand – A retrospective cohort study
Authors' conclusion
Clinically evident RA-ILD occurred in approximately 5 % of individuals with RA. Mortality was increased almost fourfold compared to the general population. Radiologic extent was the most important prognostic factor.
Study context
- Population
- Adults (≥18 years) with rheumatoid arthritis (RA) resident in the Canterbury District Health Board (CDHB) catchment area, Canterbury, New Zealand, in 2006–2008 (Period One) and 2011–2013 (Period Two), followed until 30 June 2019
- Outcome
- Prevalence and incidence of RA-ILD; risk factors for development; outcomes (mortality)
Methodological detailspopulation-based, Cox proportional hazards models
- Population-based
- Cox proportional hazards models
Main finding
As reported in the abstract
Prevalence of RA-ILD per 100,000
Period One prevalence per 100,000
10.97
95% CI 7.53,14.42
Period Two prevalence per 100,000
14.74
95% CI 10.84,18.63
Cumulative incidence of ILD at 10 years
4.47 %
95% CI 3.14, 6.14
Observational data: associations, not effects.
Further findings
Risk factors for developing RA-ILD (age-adjusted)
| HR (95 % CI) | ||
|---|---|---|
| RF positivityAdjusted for age | 3.73 (1.32,10.56) | |
| Extra-articular manifestations other than RA-ILDAdjusted for age | 4.48 (2.36,8.48) | |
| Subcutaneous rheumatoid nodulesAdjusted for age | 4.66 (2.34–9.26) | |
| 0.050.21520Hazard ratio (log scale) |
| Outcome | HR (95 % CI) | |
|---|---|---|
| Mortality by extent of ILD on CT chest>20%vs < 20 % | 4.47 (1.67,11.96) | |
| 0.050.21520Hazard ratio (log scale) |
| Outcome | Standardised mortality ratio (95 % CI) |
|---|---|
| Mortality in RA-ILD vs general population | 3.90 (2.55,5.72) |
Original publication
Rheumatoid interstitial lung disease in Canterbury, Aotearoa New Zealand – A retrospective cohort study. Semin Arthritis Rheum. Published 23 December 2023. doi:10.
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