Results of the implementation of a multidisciplinary care protocol for preventing fragility fractures following liver transplantation
Authors' conclusion
Nearly 11% of the patients developed fragility fractures during the first year after LT, despite following a CP.
Study context
- Population
- Subjects referred for liver transplantation (LT) in a multidisciplinary care protocol (CP) for preventing fractures, over a 7-year period; bisphosphonates if T-score < - 1 and/or previous fractures70% men
- Participants
- 220 subjects
- Outcome
- Incidence of fractures after LT under the CP
- Follow-up
- First year after LT
Methodological detailssingle-group, logistic regression, predictive score
- Single-group
- Logistic regression
- Predictive score
Main finding
As reported in the abstract
Fragility fractures during the first year after LT
Patients developing fractures during the first year after LT
24
10.9%
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Predictive score for fracture risk | Predictive score sensitivity 80% · specificity 72% |
Fracture risk factors (logistic regression)
- Main risk factors: age (> 50 years), history of previous fractures, postmenopausal woman
Baseline bone status before LT
- Fragility fractures before LT
- 24%
- Osteopenia
- Forty-seven percent
- Osteoporosis at lumbar spine, femoral neck and total femur
- 30%
Original publication
Results of the implementation of a multidisciplinary care protocol for preventing fragility fractures following liver transplantation. Osteoporos Int. Published 22 May 2025. doi:10.
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