Vasculitis & polymyalgia rheumatica
Relationship between histopathological features of non-infectious aortitis and the results of pre-operative 18F-FDG-PET/CT: a retrospective study of 16 patients
Authors' conclusion
In histologically proved aortitis, 18FDG-PET/CT before surgery did not detect vascular inflammation in 31% patients, and PETVAS score correlated with the degree of adventitial histopathologic inflammation.
Study context
- Population
- Histologically proven active, non-infectious aortitis with 18FDG-PET/CT within one year before surgery for aneurysm repair8 GCA, 4 isolated aortitis, 2 TAK, 1 RP, 1 RA
- Participants
- 16 participants
- Exposure
- 18FDG-PET/CT active vs inactive aortitis
- PET/CT inactiven = 5reference
- Outcome
- Detection of aortic inflammation on pre-operative 18FDG-PET/CT and correlation of arterial wall inflammation with PETVAS score
Methodological detailsmulticentre, radiologists blinded to pathology findings
- Multicentre
- Radiologists blinded to pathology findings
Main finding
As reported in the abstract
Aortic inflammation not detected by 18FDG-PET/CT
- 18FDG-PET/CT did not detect aortic inflammation
- 5/16 (31%)
- Inactive on PET/CT: significantly older
- p=0.027
- Inactive on PET/CT: lower PETVAS score
- p=0.007
- Inactive on PET/CT: lower degree of adventitial inflammation
- p=0.035
Observational data: associations, not effects.
Further findings
FDG uptake by territory
- Ascending thoracic and abdominal aorta had the highest FDG uptake among affected territories
Timing between PET/CT and surgery, serum CRP, FDG uptake per site
- No difference between PET/CT active and inactive aortitis
Original publication
Relationship between histopathological features of non-infectious aortitis and the results of pre-operative 18F-FDG-PET/CT: a retrospective study of 16 patients. Clin Exp Rheumatol. Published 9 October 2022. doi:10.
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