In rheumatoid arthritis (RA) patients without prevalent cardiovascular diseases (CVD), incident CVD is mainly associated with traditional risk factors: A 20-year follow-up in the CARRÉ cohort study
Authors' conclusion
In RA patients without prevalent CVD the increased CVD risk is mainly attributable to increased presence of traditional risk factors.
Study context
- Population
- RA patients without prevalent CVD (CARRÉ cohort, >20-year follow-up) and a reference cohort enriched for type 2 diabetes mellitus (DM)reference cohort n = 2484
- Participants
- 238 / 117 / 1,282
- Exposure
- RA and DM patients vs non-RA/-DM controls
- RAn = 238
- DMn = 117
- Controlsn = 1,282reference
- Outcome
- Incident CVD events
- Follow-up
- More than 20 years
Methodological detailsCox proportional hazard models, adjusted for baseline SCORE1, reference cohort enriched for type 2 DM
- Cox proportional hazard models
- Adjusted for baseline SCORE1
- Reference cohort enriched for type 2 DM
Main finding
As reported in the abstract
CVD events, patients without prevalent CVD, adjusted for SCORE1
Each group vs controlsHazard ratio (95% CI)
RAno relevant 'RA-specific' risk remains
1.16(0.88–1.53)
DM'DM-specific' risk retained
1.73(1.24–2.42)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CVD events, all cases (incl. prevalent CVD), adjustedRAvs Controls'RA-specific' risk confirmed | 1.50 (1.19–1.89) | |
| 0.512Hazard ratio (log scale) |
Original publication
In RA patients without prevalent CVD, incident CVD is mainly associated with traditional risk factors: A 20-year follow-up in the CARRÉ cohort study. Semin Arthritis Rheum. Published 12 November 2022. doi:10.
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