Systemic sclerosis & Raynaud's
Pulmonary involvement in systemic sclerosis: can sex play a role?
Authors' conclusion
Our results showed that, although ILD is more common in male SSc patients, SAD was more prevalent among female individuals. Importantly, female sex remained an independent predictor of SAD.
Study context
- Population
- Consecutive patients with systemic sclerosis (SSc) visiting the authors' department up to January 2024female-to-male ratio 6:1
- Participants
- 393 patients
- Exposure
- Female vs male patients with SSc
- Outcome
- Pulmonary involvement, primarily small airway disease (SAD)
Methodological detailsconsecutive patients, multivariate analysis
- Consecutive patients
- Multivariate analysis
Main finding
As reported in the abstract
Small airway involvement
- Female patients had a lower maximal-mid expiratory flow rate (MMEF)
- Female patients had a higher ratio of residual volume to total lung capacity
- Sex remained an independent predictor of MMEF in multivariate analysis
Observational data: associations, not effects.
Further findings
ILD
- Male patients had a higher prevalence of ILD and shorter time until ILD diagnosis
Other disease features
- Median time to diagnosis after Raynaud's onset significantly longer for female patients
- ECG abnormalities more common in male patients
- Telangiectasias, calcinosis and arthralgias more common in female patients
Original publication
Pulmonary involvement in systemic sclerosis: can sex play a role? Rheumatology (Oxford). Published 25 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →