Spondyloarthritis & psoriatic arthritis
Psoriasis patients with psoriatic arthritis demonstrate a reduced regulatory capacity for neutrophil elastase
Authors' conclusion
PsA patients show a reduced NE inhibitor expression in both the skin and blood compartment compared with those with plaque PsO only.
Study context
- Population
- Patients with plaque PsO with and without PsA, healthy controls; independent PsA and arthritis validation cohorts
- Comparison
- PsO with PsA vs plaque PsO without PsA vs healthy controls
- Outcome
- Protein expression of NE and elafin in epidermal samples and serum
Methodological detailsmatched epidermal and serum samples, validation in independent cohorts
- Matched epidermal and serum samples
- Validation in independent cohorts
Main finding
As reported in the abstract
- Neutrophil elastase (NE):elafin ratio differed significantly between PsO and PsA patients
- Elafin expression reduced in PsA vs plaque PsO
- NE:secretory leucocyte protease inhibitor ratio increased in PsA vs PsO without PsA, healthy controls and other arthritis
Original publication
Psoriasis patients with psoriatic arthritis demonstrate a reduced regulatory capacity for neutrophil elastase. Rheumatology (Oxford). Published 22 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →