Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration
Authors' conclusion
In this study, we have identified AEBP1 as a tissue marker for monitoring the severity of disc degeneration in humans.
Study context
- Population
- Adults with degenerate intervertebral discs (tissue and matched plasma)Intervertebral disc (IVD) tissues with matched plasma
- Participants
- 35 adults
- Comparison
- Severe vs mild degenerate intervertebral disc tissue and matched plasma
- Outcome
- Proteomic differences in tissue and plasma between mild and severe IVD degeneration
Methodological detailsproteomic profiling (mass spectrometry), matched tissue and plasma, validation by immunohistochemistry and qRT-PCR
- Proteomic profiling (mass spectrometry)
- Matched tissue and plasma
- Validation by immunohistochemistry and qRT-PCR
Main finding
As reported in the abstract
Proteins with significantly increased abundance in severe vs mild degenerated IVD tissue
31
Proportion of these proteins that were matrisome-related
more than 40%
AUC of AEBP1 protein levels distinguishing mild from severe degenerated IVD tissue
0.768
95% CI 0.60–0.93
Original publication
Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration. Arthritis Res Ther. Published 10 February 2025. doi:10.
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