Vasculitis & polymyalgia rheumatica
Prospective assessment of glucocorticoid toxicity in rheumatology practice: a focus on the glucocorticoid toxicity index
Authors' conclusion
It was shown that GTI scores were associated with cumulative GC-doses and vasculitis patients in the GC-naive patients had higher GTI scores than inflammatory arthritis.
Study context
- Population
- Patients with inflammatory arthritis, connective tissue disease and vasculitis at a rheumatology outpatient clinic48.7% glucocorticoid (GC)-naive
- Participants
- 156 patients
- Exposure
- GC-naive vs GC-experienced patients
- Outcome
- GC toxicity measured by GTI (GTI-AIS and GTI-CWS)
- Follow-up
- Baseline, 3rd month and 6th month
Methodological detailsgeneralized estimating equations
- Generalized estimating equations
Main finding
As reported in the abstract
GTI scores
- Higher cumulative GC-dose associated with higher glucocorticoid toxicity index (GTI)-scores in both groups
- P < 0.001
- GC-naive: vasculitis higher GTI-scores than inflammatory arthritis (IA)
- P < 0.001
- GC-experienced: GTI-AIS and GTI-CWS significantly different at 3rd and 6th month
- P < 0.05
Observational data: associations, not effects.
Original publication
Prospective assessment of glucocorticoid toxicity in rheumatology practice: a focus on the glucocorticoid toxicity index. Rheumatology (Oxford). Published 23 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →