Lupus & antiphospholipid syndrome
Prevalence and target attainment of traditional cardiovascular risk factors in patients with systemic lupus erythematosus: a cross-sectional study including 3401 individuals from 24 countries
Authors' conclusion
High prevalence and inadequate cardiovascular risk factor control were observed in a large multicentre and multiethnic SLE cohort, especially among patients from middle-income compared with high-income countries and among those with coexistent antiphospholipid syndrome.
Study context
- Population
- Adult patients (aged ≥18) with systemic lupus erythematosus (SLE) followed between Jan 1, 2015, and Jan 1, 2020, 24 countries across five continents
- Participants
- 3,401 patients24 countries
- Exposure
- High-income vs middle-income countries; SLE with vs without APS
- Outcome
- Prevalence and target attainment of traditional cardiovascular risk factors
Methodological detailsmulticentre, international, 24 countries
- Multicentre
- International, 24 countries
Main finding
As reported in the abstract
Hypertension
1210 [35.6%] of 3398 patients
Obesity
751 [23.7%] of 3169 patients
Hyperlipidaemia
650 [19.8%] of 3279 patients
Observational data: associations, not effects.
Further findings
Blood pressure target attainment (<130/80 mm Hg)
P < 0.0001
HDL target attainment
P < 0.0001 for high-density lipoprotein [HDL]
Non-HDL target attainment
P = 0.013 for non-HDL
Triglyceride target attainment
P < 0.0001 for triglycerides
- Blood pressure target attainment (<130/80 mm Hg): 1170 of 2132 vs 519 of 1109 patients
- HDL target attainment: 895 of 1194 vs 386 of 751 patients
- Non-HDL target attainment: 769 of 1158 vs 453 of 745 patients
- Triglyceride target attainment: 1017 of 1257 vs 486 of 792 patients
Cardiovascular risk factor prevalence by country income
- Higher prevalence of cardiovascular risk factors in high-income vs middle-income countries
SLE with APS vs without APS (556 [20.7%] of 2681 had APS)
- SLE with APS: higher prevalence of modifiable cardiovascular risk factors and significantly lower attainment of BMI and lipid targets (LDL and non-HDL) than without APS
Original publication
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