Vasculitis & polymyalgia rheumatica
Prevalence, Predictors, and Prognosis of Serious Infections in Takayasu Arteritis: A Cohort Study
Authors' conclusion
Serious infections, which occurred in the absence of immunosuppressive treatment in approximately one-fifth of patients with TA, were associated with increased mortality in patients with TA.
Study context
- Population
- Patients with TAK
- Participants
- 238 patients
- Exposure
- TAK with vs without serious infections
- Serious infectionsn = 38
- Outcome
- Incidence, risk factors and outcomes of serious infections
Methodological detailsexponential parametric regression survival-time model
- Exponential parametric regression survival-time model
Main finding
As reported in the abstract
Serious infections
Serious infections
16%
38
- Episodes (multiple episodes in 8; 3 resulted in death)
- 50
Observational data: associations, not effects.
Further findings
Active disease at presentation
| Outcome | HR (95% CI) | |
|---|---|---|
| Mortality | 5.52 (1.75–17.39) | |
| 0.050.21520Hazard ratio (log scale) |
Mean
| Outcome | Serious infections | No serious infections |
|---|---|---|
| Indian Takayasu Arteritis Activity Score 2010 · presentation | 12.7 (SD 7.3) | 10.2 (SD 7.0) |
| Disease Extent Index in Takayasu Arteritis · presentation | 11.2 (SD 6.1) | 8.8 (SD 6.1) |
Initial episodes without corticosteroids / without disease-modifying antirheumatic drug (DMARDs)
- Not on corticosteroids
- 11/38
- Not on DMARDs
- 14/38
Infection type
- Pneumonia (most common)
- 19
- Tuberculosis
- 12
Disease Extent Index in Takayasu Arteritis · presentation
- More frequently initiated on corticosteroids or DMARDs with serious infections
Original publication
Prevalence, Predictors, and Prognosis of Serious Infections in Takayasu Arteritis: A Cohort Study. J Rheumatol. Published 1 April 2024. doi:10.
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