Systemic sclerosis & Raynaud's
Predictors of Perceived Functional Status in Early Systemic Sclerosis: A Prospective Longitudinal Study of an Early Disease Cohort
Authors' conclusion
This large, longitudinal study of early disease SSc demonstrates that severity of skin disease and socioeconomic factors such as educational level and income are important predictors of perceived functional disability in SSc.
Study context
- Population
- Patients with early systemic sclerosis (SSc) (mean disease duration 2.5 years) with baseline modified Health Assessment Questionnaire (M-HAQ) scores, GENISOS cohort1,950 M-HAQ measurements
- Participants
- 388 patients
- Outcome
- M-HAQ scores over time (predictors among clinical, demographic and socioeconomic factors)
Methodological detailslongitudinal, early disease cohort, Mean follow-up 3.9 years; median follow-up 7.2 years
- Longitudinal
- Early disease cohort
- Mean follow-up 3.9 years; median follow-up 7.2 years
Main finding
As reported in the abstract
Independent predictors of worse perceived functional disability over time (higher longitudinal M-HAQ)
- Higher longitudinal modified Rodnan skin scores correlated with higher M-HAQ scores (univariable and multivariable)
- P < 0.001
- Higher longitudinal FVC % predicted correlated with lower M-HAQ scores (univariable and multivariable)
- P < 0.001
Observational data: associations, not effects.
Further findings
Mortality by baseline M-HAQ score
| HR (95% CI) | P value | ||
|---|---|---|---|
| Higher baseline M-HAQ | 1.29 (1.09–1.52) | P = 0.003 | |
| 0.512Hazard ratio (log scale) |
Original publication
Predictors of Perceived Functional Status in Early Systemic Sclerosis: A Prospective Longitudinal Study of an Early Disease Cohort. Arthritis Care Res (Hoboken). Published 9 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →