Spondyloarthritis & psoriatic arthritis
Predictors of b/tsDMARDs discontinuation and treatment response in psoriatic arthritis: results from the British Society for Rheumatology Psoriatic Arthritis Register (BSR-PsA)
Authors' conclusion
Treatment persistence and response in PsA remain a problem and are strongly influenced by demographic factors and baseline disease severity. A better understanding of predictors of non-response may aid future risk stratification.
Study context
- Population
- Patients with psoriatic arthritis commencing b/tsDMARD therapy, British Society for Rheumatology Psoriatic Arthritis Register (BSR-PsA)participants included, 40% male, median age 51 years
- Participants
- 815 patients
- Exposure
- Predictors of b/tsDMARD discontinuation and treatment response; PDE4 inhibition compared to TNF inhibitors
- Outcome
- Baseline disease activity
- Follow-up
- Treatment start
Methodological detailsCox regression, multiple imputation with predictive mean matching, logistic regression
- Cox regression
- Multiple imputation with predictive mean matching
- Logistic regression
Main finding
As reported in the abstract
Median DAPSA
33.5
Median PASDAS
5.9
Observational data: associations, not effects.
Further findings
| Outcome | Hazard Ratio (95% CI) | |
|---|---|---|
| Drug discontinuation | 2.25 (1.45–3.50) | |
| 0.20.5125Hazard Ratio (log scale) |
- Drug discontinuation: no major differences were observed with other modes of action
Remaining on index therapy · At censoring (01-Aug-2025)
- Remained on index therapy
- 65%
- Median exposure
- 31 months
- Discontinuation due to inefficacy (of discontinuations)
- 55%
- Discontinuation due to intolerance (of discontinuations)
- 26%
Treatment response (Minimal Disease Activity (MDA), ACR50, PsARC) · 12-months
- MDA
- 24%
- ACR50
- 24%
- PsARC
- 49%
Predictors of treatment response · 12-months
- Men, younger individuals, and those who were employed were consistently more likely to achieve treatment response
- Poorer baseline clinical or patient-reported measures predicted non-response
- Based on imputed outcomes
Original publication
Predictors of b/tsDMARDs discontinuation and treatment response in psoriatic arthritis: results from the British Society for Rheumatology Psoriatic Arthritis Register (BSR-PsA). Rheumatology (Oxford). Published 27 October 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →