Predictive factors and treatment outcomes associated with difficult-to-treat rheumatoid arthritis conditions: the ANSWER cohort study
Authors' conclusion
Younger onset, higher RF titres, and comorbidities predicted D2T RA development. For managing D2T RA, aIL-6R and JAKi exhibited superior drug retention.
Study context
- Population
- RA patients treated with bDMARDs or Janus kinase inhibitors (JAKi) in Japan (ANSWER cohort)ANSWER cohort
- Participants
- 3,623 patients
- Exposure
- Predictors of D2T RA; aIL-6R and JAKi vs TNFi for treatment retention
- Outcome
- Predictive factors for D2T RA (first two criteria of the EULAR D2T RA definition)
Methodological detailsmultivariate Cox proportional hazards modelling
- Multivariate Cox proportional hazards modelling
Main finding
As reported in the abstract
Hazard ratio (95% CI)
Age over 75vs Age under 65
0.46(0.31–0.69)
Higher RF titres
1.005(1.00–1.01)
Higher CDAI
1.02(1.01–1.03)
Lower MTX dosage
0.97(0.95–0.99)
Hypertension
1.53(1.2–1.95)
Diabetes
1.37(1.09–1.73)
- Met the first two criteria of the EULAR D2T RA definition (D2T RA)
- 450 (12.4%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Discontinuation due to ineffectivenessaIL-6Rvs TNF inhibitors | 0.53 (0.37–0.75) | |
| Discontinuation due to ineffectivenessJAKivs TNF inhibitors | 0.64 (0.46–0.90) | |
| 0.20.5125Hazard ratio (log scale) |
Safety
Discontinuation due to toxic adverse events with oral GC use
| HR (95% CI) | ||
|---|---|---|
| Oral GC usage | 1.65 (1.11–2.47) | |
| 0.512Hazard ratio (log scale) |
Original publication
Predictive factors and treatment outcomes associated with difficult-to-treat rheumatoid arthritis conditions: the ANSWER cohort study. Rheumatology (Oxford). Published 9 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →