Predicting Disease Activity in Rheumatoid Arthritis With the Fibromyalgia Survey Questionnaire: Does the Severity of Fibromyalgia Symptoms Matter?
Authors' conclusion
Higher levels of FM symptoms weakly predicted worse disease activity after treatment. The primary factor that informed the FSQ's prediction of disease activity was the spatial extent of pain, as measured by the WPI.
Study context
- Population
- Patients with active rheumatoid arthritis (RA) followed for 12 weeks after initiation or change of disease-modifying antirheumatic drug (DMARD) therapy
- Participants
- 192 patients
- Outcome
- Association between baseline FSQ score and follow-up DAS28-CRP
- Follow-up
- 12 weeks
Methodological detailsmultiple linear regression adjusted for clinical and demographic variables
- Multiple linear regression adjusted for clinical and demographic variables
Main finding
As reported in the abstract
FSQ score and follow-up DAS28-CRP (multiple linear regression) · 12 weeks after DMARD initiation
- Fibromyalgia Survey Questionnaire (FSQ) score independently associated with elevated DAS28-CRP, B
- 0.04
- P
- P = 0.01
Observational data: associations, not effects.
Further findings
Widespread Pain Index (WPI) and follow-up DAS28-CRP
- WPI significantly associated with increased DAS28-CRP, B
- 0.08
- P
- P = 0.001
Symptom Severity Scale (SSS) and follow-up DAS28-CRP
- SSS not significantly associated with DAS28-CRP, B
- −0.03
- P
- P = 0.43
Original publication
Predicting Disease Activity in Rheumatoid Arthritis With the Fibromyalgia Survey Questionnaire: Does the Severity of Fibromyalgia Symptoms Matter? J Rheumatol. Published 15 December 2022. doi:10.
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