PM 10 increases mortality risk in rheumatoid arthritis-associated interstitial lung disease
Main finding · Mortality, high vs low PM10 exposureResult — go to the resultHazard ratio 1.68 95% CI 1.11–2.52Authors' conclusion
Our results indicated that high PM10 exposure may be associated with mortality in patients with RA-ILD.
Study context
- Population
- Patients with RA-ILD (mean age 61.7 years; male 44.3%)median follow-up 4.8 years
- Participants
- 309 patients
- Exposure
- High vs low long-term exposure to PM10 and NO2
- Outcome
- Mortality (death or lung transplantation)
Methodological detailsCox proportional hazards model adjusted for individual-level and area-level characteristics, national-scale exposure prediction model
- Cox proportional hazards model adjusted for individual-level and area-level characteristics
- National-scale exposure prediction model
Main finding
Mortality, high vs low PM10 exposure
Hazard ratio
1.68
95% CI 1.11–2.52
P = 0.013
High exposurevs Low exposure
HR 1.68 (95% CI 1.11–2.52); P = 0.013
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Mortality, highvs low PM10 exposure, patients aged <65 years (subgroup) | 1.98 (1.02–3.85) | P = 0.045 | |
| 0.20.5125Hazard ratio (log scale) |
Death or lung transplantation
- Patients who died or underwent lung transplantation
- 40.8%
- Annual average PM10 concentration
- 56.3 μg/m³
- Annual average NO2 concentration
- 22.4 ppb
Original publication
PM 10 increases mortality risk in rheumatoid arthritis-associated interstitial lung disease. RMD Open. Published 8 February 2024. doi:10.
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