Plasma Proteomics Identifies Thousand‐and‐One–Amino Acid Kinase 3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target
Authors' conclusion
TAOK3 serves as a potential biomarker for bone destruction in active RA and as a therapeutic target for precision monitoring and intervention.
Study context
- Population
- Patients with rheumatoid arthritis (RA) and healthy controls; validation cohorts N1 = 50 and N2 = 10validation cohorts N1 = 50, N2 = 10
- Participants
- 160 vs 40
- Comparison
- Active RA vs remitted RA; RA vs healthy controls
- RAn = 160
- Healthy controlsn = 40reference
- Outcome
- Novel plasma biomarkers linked to bone destruction in active RA
Methodological detailsplasma proteomics (data-independent acquisition mass spectrometry), two independent validation cohorts, in vitro FLS studies, collagen-induced arthritis (CIA) mouse model
- Plasma proteomics (data-independent acquisition mass spectrometry)
- Two independent validation cohorts
- In vitro FLS studies
- CIA mouse model
Main finding
As reported in the abstract
Plasma proteins linked to bone destruction in active RA
Plasma proteins identified
4,998
Proteins differentially expressed between active and remitted RA
506
TAOK3 combined with CRP, diagnostic accuracy for active RA (AUC)
0.915
Further findings
Functional studies (FLSs in vitro, CIA mice in vivo)
- TAOK3 knockdown suppressed the tumor-like phenotype of FLSs and down-regulated MMP1/2/3 and cathepsin K
- TAOK3 overexpression promoted pannus cell-mediated bone erosion, mitigated by TAOK3-targeted inhibitor
- TAOK3 inhibition showed therapeutic effects in CIA mice
Original publication
Plasma Proteomics Identifies Thousand‐and‐One–Amino Acid Kinase 3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target. Arthritis Rheumatol. Published 17 February 2026. doi:10.
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