Persistent high prevalence of modifiable cardiovascular risk factors among patients with osteoarthritis in the UK in 1992–2017
Authors' conclusion
A consistently higher long-term prevalence of MCVRFs was observed in individuals with OA compared to those without OA.
Study context
- Population
- Patients aged 35 years and over, UK Clinical Practice Research Datalink GOLD database, 1992–2017215,190 osteoarthritis (OA) patients
- Exposure
- OA vs non-OA individuals
- OAn = 215,190
- Outcome
- Annual and period prevalence and PRRs of individual and clustering (≥1, ≥2 and ≥3) MCVRFs (smoking, hypertension, type 2 diabetes, obesity, dyslipidaemia)
Methodological details1:1 age-matched, sex-matched, practice-matched and index year-matched, Poisson regression with multiple imputations
- 1:1 age-matched, sex-matched, practice-matched and index year-matched
- Poisson regression with multiple imputations
Main finding
As reported in the abstract
Prevalence of MCVRFs
- Annual prevalence of modifiable cardiovascular risk factors (MCVRFs) increased in OA population between 1992 and 2017
- Annual prevalence consistently higher in OA vs non-OA between 2004 and 2017
- Trends towards increased or stable annual PRRs for individual and clustering MCVRFs
- 26-year period prevalence of single and clustering MCVRFs significantly higher in OA vs non-OA
Observational data: associations, not effects.
Further findings
Period PRRs by region, sex and age
- Period PRRs higher in Southern England, women and increased with age for most MCVRFs except obesity, which had the higher PRR in the youngest age group
Original publication
Persistent high prevalence of modifiable cardiovascular risk factors among patients with osteoarthritis in the UK in 1992–2017. RMD Open. Published 30 August 2023. doi:10.
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