Peripheral but not axial muscle mass is associated with early mortality in bone metastatic lung cancer patients at diagnosis
Performance · Early mortality (<6 months)Result — go to the resultHazard ratio 0.29 95% CI [0.15; 0.57]Authors' conclusion
Peripheral muscle mass (standardized ALM by DEXA) but not axial muscle mass (SMI assessed by CT) was associated with early mortality (<6months) suggesting that cancer-induced muscle loss would affect differently appendicular muscles and axial muscles.
Study context
- Population
- Patients with synchronous bone metastases from lung adenocarcinoma at diagnosis, confirmed by bone biopsy47 (72%) male
- Participants
- 65 patients
- Comparison
- Peripheral muscle mass vs axial muscle mass as predictors of mortality
- Appendicular lean mass (ALM)n = 46
- Outcome
- Early mortality (<6 months)
- Follow-up
- 6 months
Performance
As reported in the abstract
Hazard ratio
0.29
95% CI [0.15; 0.57]
P < 0.001
By group
ALM
0.87
0.76; 0.97
AUC (6-month survival)
Peripheral muscle mass (ALM by DXA)vs axial muscle mass (SMI by CT) as predictors of mortality
HR 0.29 (95% CI [0.15; 0.57]); P < 0.001
Further findings
Later mortality (>6 months)
- ALM not associated with later mortality
Correlation of muscle mass indicators
- Skeletal muscle index (SMI) indicators correlated with each other (rho)
- 0.3 to 0.7
- SMI moderately correlated with ALM (rho)
- 0.1 to 0.7
Original publication
Peripheral but not axial muscle mass is associated with early mortality in bone metastatic lung cancer patients at diagnosis. Joint Bone Spine. Published 11 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →