Performance of Gender-Age-Physiology (GAP) and ILD-GAP models in predicting lung transplant or death in interstitial pneumonia with autoimmune features
Authors' conclusion
In patients with IPAF, the GAP model performed well as a predictor of lung transplantation or death at 2 years and 3 years from ILD diagnosis in patients with GAP stage 1 and GAP stage 2 disease.
Study context
- Population
- Adults with interstitial pneumonia with autoimmune features (IPAF) at an academic medical centre (mean age 58 years; 62% female)
- Participants
- 94 adults
- Exposure
- GAP model vs ILD-GAP model for predicting lung transplant or death
- Outcome
- Composite of:
- Lung transplantation
- Death
Methodological detailssingle academic medical centre, prognostic model validation
- Single academic medical centre
- Prognostic model validation
Main finding
As reported in the abstract
Discrimination for lung transplantation or death (c-index)
GAP
0.664
c-index · 95% CI 0.547–0.781
ILD-GAP
0.569
c-index · 95% CI 0.440–0.697
Observational data: associations, not effects.
Further findings
Calibration of GAP model in GAP stage 1 or 2 (subgroup) · 2 and 3 years
- Calibration of the GAP model satisfactory for lung transplantation or death
Original publication
Performance of GAP and ILD-GAP models in predicting lung transplant or death in interstitial pneumonia with autoimmune features. Rheumatology (Oxford). Published 21 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →