Lupus & antiphospholipid syndrome
PD-1/PD-L1 governed cross-talk of exhausted CD8+ T and memory B cells in systemic lupus erythematosus
Authors' conclusion
The PD-1/PD-L1 signalling pathway, which governs the crosstalk between exhausted CD8+ T cells and activated memory B cells, is a mechanistic explanation for insufficient interferon-γ response in patients with SLE.
Study context
- Population
- Outpatients with systemic lupus erythematosus (SLE) or other rheumatic musculoskeletal diseases (RMDs), 2020–2023, and healthy donors
- Participants
- 104 / 225 / 20
- Comparison
- SLE vs other RMDs vs healthy donors (indeterminate QFT rate); SLE with indeterminate vs negative QFT
- SLEn = 104
- RMDn = 225reference
- Healthy donorsn = 20
- Outcome
- Rate of indeterminate QFT results
Main finding
As reported in the abstract
Indeterminate QFT results
Further findings
Active nephritis in SLE, indeterminate vs negative QFT
Mean
| Outcome | SLE indeterminate QFT | SLE negative QFT | P value |
|---|---|---|---|
| Disease activity (SLEDAI-2K) in SLE, indeterminate vs negative QFT | 10.94 | 4.02 | P < 0.0001 |
Original publication
PD-1/PD-L1 governed cross-talk of exhausted CD8+ T and memory B cells in systemic lupus erythematosus. RMD Open. Published 17 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →