Part 5: Allogeneic HSCT in refractory SJIA with lung disease; recent cases from centers in North America & Europe
Authors' conclusion
There was unanimous agreement about the importance of long-term registries to address these questions.
Study context
- Population
- Patients with refractory sJIA (with lung disease) who have failed all available medications, undergoing allogeneic HSCT
Methodological detailsexpert discussion (NextGen 2022 conference), Discussion focused on optimal timing of HSCT, need for good control of inflammatory sJIA activity before HSCT, and role of reduced intensity conditioning regimens (remote concern of increased sJIA relapse risk)
- Expert discussion (NextGen 2022 conference)
- Discussion focused on optimal timing of HSCT, need for good control of inflammatory sJIA activity before HSCT, and role of reduced intensity conditioning regimens (remote concern of increased sJIA relapse risk)
Main finding
As reported in the abstract
- Short-term, transplanted patients either achieved sJIA remission or reduced burden of disease, despite complicated post-HSCT course
- Unanimous agreement about the importance of long-term registries
Original publication
Part 5: Allogeneic HSCT in refractory SJIA with lung disease; recent cases from centers in North America & Europe. Pediatr Rheumatol Online J. Published 5 January 2024. doi:10.
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