Paraproteinemias in Sjögren disease: cryoglobulinemia and serum monoclonal gammopathy identify distinct clinical phenotypes and differential lymphoma susceptibility
Main finding · LymphomaResult — go to the resultOdds ratio 6.30 95% CI 2.66–14.92Authors' conclusion
Cryoglobulinemia in SjD associates with vasculitic disease activity, whereas the coexistence of serum MC and cryoglobulins identifies a distinct, high-risk subset characterized by advanced B-cell expansion and increased lymphoma susceptibility.
Study context
- Population
- Patients with sjögren disease (SjD) in the Italian GRISS registry
- Participants
- 1,202 patients
- Exposure
- Monoclonal component (MC)-alone, CRYO-alone and MC+CRYO vs SjD without paraproteinemia
- MC-alonen = 58
- CRYO-alonen = 32
- MC+CRYOn = 35
- Controlsn = 1,077reference
- Outcome
- Lymphoma diagnosis
Methodological detailsretrospective, multicentre, Italian GRISS registry, logistic regression adjusted for confounders
- Retrospective
- Multicentre
- Italian GRISS registry
- Logistic regression adjusted for confounders
Main finding
Lymphoma
Odds ratio
6.30
95% CI 2.66–14.92
P < 0.001
MC+CRYOvs Controls
OR 6.30 (95% CI 2.66–14.92); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Lab lymphoproliferative risk markers and ClinESSDAI vasculitic domains with cryoglobulinemia (CRYO-alone or MC+CRYO)
- RF
- P < 0.001
- Low C4
- P < 0.001
- Cutaneous
- P < 0.001
- Renal
- P < 0.05
- PNS
- P < 0.001
ClinESSDAI lymphoproliferative domains in MC+CRYO
- Constitutional
- P < 0.05
- Glandular
- P < 0.05
- Hematological
- P < 0.001
- Lymphadenopathy
- P < 0.001
Original publication
Paraproteinemias in Sjögren disease: cryoglobulinemia and serum monoclonal gammopathy identify distinct clinical phenotypes and differential lymphoma susceptibility. Semin Arthritis Rheum. Published 19 April 2026. doi:10.
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